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. 2013 Feb 14;8(2):e56015. doi: 10.1371/journal.pone.0056015

Figure 6. IgE-induced ASMC proliferation needs both IgE receptors and Erk1/2 and p38 MAPK.

Figure 6

(A) The dose-dependent effect of IgE on ASMC proliferation over 48 hours determined by manual cell counts. (B) The role of IgE-receptors on IgE-induced ASMC proliferation. (C) MAPK signalling in IgE-induced ASMC proliferation. Bars represent the mean ± S.E.M. of six asthma ASMC and seven non-asthma ASMC lines. All experiments were performed in triplicate. (D) Viability of ASMC in the presence of increasing concentrations of MAPK inhibitors PD98059 and SB203580. Experiments were performed in triplicate in four ASMC lines and data represent the mean ± S.E.M.