Table 1. Summary of the incidence and progression rates of trachomatous scarring.
Progression Factor | Sample Size | Follow-Up Interval | Rate | Setting | Prospective Design? | Associated Factors |
Incident conjunctival scarring [28], [151] | 367 | 5 y | 20.4% | Tanzania | Yes | In children <10 y: active disease/persistent infection; female gender; age |
Incident conjunctival scarring [24] | 236 (age <7 y) | 7 y | 29.2% versus 9.6% | Tanzania | No | Higher rate was in children with severe-constant active disease; female gender; age |
Worsening of conjunctival scarring [151] | 85 | 5 y | 47.1% | Tanzania | Yes | Not specified |
Worsening of conjunctival scarring [25] | 213a | 14 y | 68.5% | Tunisia | No | Active disease; household density |
From conjunctival scarring to trichiasis [26] | 523 (all women) | 7 y | 9.2% | Tanzania | No | Active disease; chlamydial infection; increasing age |
From conjunctival scarring to trichiasis [152] | 297 | 12 y | 6.4% | Gambia | No | Mandinka ethnicity |
From conjunctival scarring to trichiasis [27] | 4,898 | 5 y | 3.2%–15.1% | Tanzania | Nob | Increasing age |
From minor to major trichiasis [153] | 55 | 1 y | 33% | Gambia | No | None mentioned |
From minor to major trichiasis [27] | 75 | 4 y | 37% | Gambia | No | Conjunctival inflammation |
From unilateral to bilateral trichiasis [153] | 46 | 1 y | 46% | Gambia | No | Baseline pannus; hot ash as an aid to epilation |
From conjunctival scarring +/− trichiasis to corneal scarring [152] | 302 | 12 y | 6.0% | Gambia | No | Baseline trichiasis |
From trichiasis to corneal scarring [27] | 211 | 4 y | 7.6% | Gambia | No | Increasing trichiasis severity; conjunctival inflammation |
From trichiasis to corneal opacity [154] | 4,898 | 10 y | 27.2%–53.5% | Tanzania | Nob | Increasing age |
Worsening of corneal scarring [153] | 96 | 1 y | 34% | Gambia | No | Conjunctival inflammation; bacterial growth |
Including 82 people with no scarring at baseline.
Estimated incidence rates based on age-specific prevalence of scarring, trichiasis, and corneal opacity among women.