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MCP-1 expression is downregulated by inhibition of endogenous PGE2 production. (A, C and E) MCP-1 mRNA levels are shown to decrease after melanoma cells are treated with NS398, COX-2 siRNA and PDTC, respectively. (B, D and F) NS398, COX-2 siRNA and PDTC inhibit secretion of MCP-1 protein into the melanoma cell culture supernatant. *P<0.01 vs. normal. MCP-1, macrophage chemoattractant protein-1; COX-2, cyclooxygenase-2; PGE2, prostaglandin E2.
