Table V.

Pearson’s correlation coefficient between IC₅₀ values for 5-FU or CDDP and mRNA expression level.

	Pearson’s correlation coefficient (r)
Function and gene	5-FU	CDDP
Transport
SLC22A1	−0.189	0.333
SLC22A2	−0.764	−0.574
SLC22A3	ND	ND
SLC23A2	−0.790	−0.302
SLC31A1	−0.477	−0.132
ABCB1	−0.788	−0.215
ABCC1	−0.150	−0.530
ABCC2	0.992b	0.706
ABCC3	−0.659	−0.179
ABCC4	−0.470	−0.315
ABCC5	0.573	0.234
ABCC6	ND	ND
ABCG2	−0.244	0.398
ATP7A	−0.199	0.451
ATP7B	−0.485	−0.314
DNA repair
ERCC1	−0.638	−0.041
ERCC2	−0.533	0.019
ERCC3	−0.439	0.187
XPA	−0.463	−0.284
Rad51	−0.756	−0.523
BRCA1	−0.653	−0.274
BRCA2	−0.455	−0.049
HMGB1	−0.341	−0.507
HMGB2	0.010	0.125
MLH1	−0.369	0.269
MSH2	0.913a	0.719
PMS2	−0.363	−0.365
RPP25	−0.486	−0.561
Metabolism
GSTP1	−0.401	0.121
GCLC	0.032	−0.321
GCLM	0.287	−0.011
TYMS	0.163	−0.211
DPYD	0.881	0.863
UMPS	−0.522	−0.379
MTHFR	−0.319	−0.074

ND, not detected.

^aP<0.05 and

^bP<0.01 significant correlations between IC₅₀ values and mRNA expression levels. 5-FU, 5-fluorouracil; CDDP, cisplatin.