Fig. 1.

Genes regulated by OPP in the liver, spleen and heart. a Genes up-regulated in the liver unfolded protein response network. Genes involved in the unfolded protein response up-regulated by OPP include Tra1 and Vcp. b Genes down-regulated by OPP in the spleen antigen presentation network. Genes encoding MHC II molecules such as those belonging to the HLA-D family, genes of antigenic markers such as Cd74, Cd82, Cd83 and Cd86 as well as genes encoding chemokines such as Ccl5, Ccl19, Cxcl9 and Xcl1 were down-regulated by OPP. The down-regulation of genes encoding MHC II molecules could be caused by the down-regulation of C2ta. c Genes up-regulated by OPP in the heart antioxidant pathway. Genes involved in antioxidant activity such as Gpx1 and Mgst1 were up-regulated by OPP