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Illustration of the E-cadherin missense mutations' location and the binding region of E-cadherin partners. Location of the germline E-cadherin mutations, identified in HDGC families, used in this study. The location of the protein signal peptide, precursor sequence, extracellular domain, transmembrane domain (TM) and cytoplasmic domain, as well as the binding domain of p120, Hakai, PIPKIγ and β-catenin are represented.
