Figure 7.

Cytoplasmic E-cadherin missense mutations are less invasive than the extracellular ones. (a) CHO cells stably transfected with the empty vector (Mock), WT E-cadherin or different mutants were analyzed for cell–cell aggregation ability by slow aggregation assays. The images shown are representative of three independent experiments. (b) For each mutant cell line, matrigel invasion assays were performed. The graph shows the relative number of invasive cells±SE of four independent experiments (*P≤0.05 and ***P≤0.001).