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(a) Final ligand-based pharmacophore model with the potent, ABHD6 selective inhibitor WWL70 overlaid (grey carbons). (b) More stringent ligand-based pharmacophore model with the potent inhibitors 33e (cyan carbons) and JZL195 (magenta carbons) overlaid. Orange spheres require aromatic interactions, green spheres are hydrophobic, and cyan spheres are hydrogen-bond acceptor projections. Figures generated with the PyMOL Molecular Graphics System, Version 1.4.1 Schrödinger, LLC.
