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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: J Thorac Cardiovasc Surg. 2012 May 22;145(3):854–861. doi: 10.1016/j.jtcvs.2012.03.079

Figure 5.

Figure 5

Combined kinetics of both undifferentiated, CD45+Col1+CXCR4+ fibrocytes in tracheal allografts, as determined by flow cytometry, and tracheal tissue collagen deposition, as determined by Direct Red 80 densitometry of tracheal allograft sections. Kinetics of control, Goat IgG F(ab′)2 treated animals (A) show a more gradual and less complete decrease in tracheal allograft undifferentiated fibrocyte number with a concomitant more rapid and greater increase in tracheal collagen deposition as compared to anti-CXCL12 F(ab′)2 treated animals (B). Kruskal-Wallis analysis demonstrates that both control and anti-CXCL12 fibrocyte populations (p<0.001) and tracheal collagen deposition (p<0.001) are significantly different.