Table 1.

Analysis of integrin function in transgenic mouse models of fibrosis

Integrin	Organ	Model of fibrosis	Manipulation	Summary	Reference
αvβ6	Lung	Bleomycin	Global knockout of αvβ6	Absence of β6 markedly attenuates bleomycin-induced lung fibrosis via a reduction in activation of latent TGFβ1	Munger et al. (1999)6
αvβ6	Lung	Radiation	Global knockout of αvβ6	Absence of β6 protects against radiation-induced lung fibrosis	Puthawala et al.(2008) (2008)20
αvβ6	Kidney	Mouse model of Alport syndrome (Col4A3−/− mice)	Global knockout of αvβ6	Absence of β6 attenuates renal fibrosis in β6-deficient Alport mice	Hahm et al. (2007)43
αvβ6	Kidney	Unilateral ureteric obstruction (UUO)	Global knockout of αvβ6	Absence of β6 attenuates UUO-induced renal fibrosis	Ma et al. (2003)44
αvβ6	Liver	Bile duct ligation	Global knockout of αvβ6	Absence of β6 attenuates acute biliary fibrosis	Wang et al. (2007)37
αvβ8	Lung	IL-1β and allergen induced lung injury	Conditional knockout of αvβ8 in fibroblasts	Reduced airway remodelling and dampening of adaptive immunity	Kitamura et et al. (2011)27
α3β1	Lung	Bleomycin	Conditional knockout of α3β1 in epithelial cells	Decreased lung fibrosis via a reduction in β-catenin/Smad signalling and EMT	Kim et al. (2009)32
β1	Skin	Subcutaneous injection of bleomycin	Conditional knockout of β1 in fibroblasts	Deletion of β1 integrin protects against bleomycin-induced skin fibrosis	Liu et al. (2009)50