Table 2.

Addition of freshly activated encephalitogenic cells exacerbates chronic classical experimental autoimmune encephalomyelitis (cEAE) disease regardless of the capacity of new cells to produce interferon‐γ (IFN‐γ)

Transferred cells1	Incidence of nEAE (Peak CS ± SD)2	Incidence of 2nd cEAE (Peak CS ± SD)2
Day 0 WT Day 90 WT	0/12	12/12 (3·3 ± 1·0)
Day 0 WT Day 90 IFN‐γ−/−	11/12 (2·4 ± 1·1)	12/12 (3·6 ± 0·8)
Day 0 HBSS Day 90 IFN‐γ−/−	10/10 (2·8 ± 1·3)	0/10
Day 0 WT Day 90 OVA	0/10	0/10

¹Transferred cells: Either 5 × 10⁶ wild‐type MOG_35–55‐specific CD4⁺ T cells (WT) or diluent (Hanks’ balanced salt solution; HBSS) was administered at the start of the experiment (where MOG_35–55 is a peptide comprising amino acids 35 to 55 of the myelin oligodendrocyte glycoprotein). After 90 days mice received 5 × 10⁶ wild‐type MOG_35–55‐specific CD4⁺ T cells (WT), 5 × 10⁶ IFN‐γ‐deficient MOG_35–55‐specific CD4⁺ T cells (IFN‐γ^−/−), or 5 × 10⁶ wild‐type ovalbumin‐specific CD4⁺ T cells (OVA).

²(Peak CS ± SD): The mean peak clincial score and standard deviations for each group are shown.