Table 1.
Resident cDCs | Migratory DCs | |||||
---|---|---|---|---|---|---|
CD8+ | CD11b+ | CD11b− CD103+ | CD11b+ CD103− | CD11b− CD103− | mLCs | |
MHC I presentation | ++ | ++ | ++ | ++ | ++ | ++ |
Cross-presentation | ++ | + [18–22] | ++ | + [23–25] | + [25,26] | |
Apoptotic cell uptake | ++ | + [91] | ++ | |||
MHC II presentation | ++ | ++ | ++ | ++ | ++ | ++ |
IL-12 production | ++ | + [12,13] | ||||
Th1 induction | ++ | + [14–16] | ++ | + [92,93] | ||
Th2 induction | + [14] | ++ | + [92] | ++ | ++ | |
Th17 induction | + [94] | + [95,96] | ++ | + [97] | + [97] | + [49] |
iTreg induction | ++ | + [98,99] | ++ | + [95] | ||
Tolerance committed | + [8] | |||||
Humoral immunity | ++ | ++ | ++ | ++ | ++ | ++ |
For a comprehensive set of DC reviews, see Immunology Reviews, 2010, volume 234(1). Commonly attributed subset functions are denoted with ++. MHC: major histocompatibility complex; IL: interleukin; Th: T helper; iTreg: induced regulatory T cells.