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. 2013 Jan 3;171(2):171–185. doi: 10.1111/cei.12013

Fig. 6.

Fig. 6

Vitamin D (VD) plasma levels and immune status in VD-deficient and non-deficient patients with type 1 diabetes (T1D) over a period of 6 months. Two blood samples of VD-deficient (< 20 μg/ml 25D at begin of the study) (red) and non-deficient (black) patients with T1D collected over a mean interval of 6 months were analysed for the VD plasma levels and immune status. (a) 25D and 1,25D plasma levels; (b) frequency of plasmacytoid dendritic cells (pDCs) [Linage cocktail 3 (Lin3–), CD303+, CD123+, CD11c+], myeloid dendritic cells (mDCs) (Lin3–, CD303–, CD123lo, CD11chi, CD4+), regulatory T cells (Tregs) (CD4+, CD25+, forkhead box protein 3 (FoxP3)+; CD8+, CD25+, FoxP3+) and (c) interferon (IFN)-γ, interleukin (IL)-17 or IL-4-producing CD4 and CD8 T cells after overnight stimulation with phorbol myristate acetate (PMA)/ionomycin. Straight lines: male; dashed lines: female.