Table 1.
Distribution of vitamin D (VD)-related polymorphisms in the type 1 diabetes (T1D) patient cohort
| Polymorphism | Genotype | % |
|---|---|---|
| HLA DR/DQ | T1D risk | 75,5 |
| Other | 24,5 | |
| CYP24A1 | CC | 27,9 |
| rs2248137 | CG | 49,1 |
| GG | 23,0 | |
| CYP24A1 | AA | 36,1 |
| rs2296241 | AG | 54,1 |
| GG | 9,8 | |
| CYP24A1 | TT | 21,3 |
| rs927650 | TC | 50,8 |
| CC | 27,9 | |
| CYP27B1 | AA | 9,5 |
| rs10877012 | AC | 54,0 |
| CC | 36,5 | |
| CYP27B1 | TT | 48,3 |
| rs4646536 | TC | 43,3 |
| CC | 8,3 | |
| CYP2R1 | AA | 7,9 |
| rs1074657 | AG | 60,3 |
| GG | 31,8 | |
| CYP2R1 | AA | 17,7 |
| rs12794714 | AG | 43,5 |
| GG | 38,7 | |
| DBP | GG | 19,7 |
| Hae III | GT | 59,0 |
| rs7041 | TT | 21,3 |
| DBP | CC | 37,7 |
| Sty I | AC | 54,1 |
| rs4588 | AA | 8,2 |
| VDR | AA | 34,9 |
| Apa I | Aa | 42,9 |
| rs7975232 | aa | 22,2 |
| VDR | BB | 23,8 |
| Bms I | Bb | 44,4 |
| rs1544410 | bb | 31,7 |
| VDR | FF | 34,4 |
| Fok I | Ff | 45,9 |
| rs10735810 | ff | 19,7 |
| VDR | TT | 41,3 |
| Taq I | Tt | 38,1 |
| rs731236 | tt | 20,6 |
Human leucocyte antigen (HLA) type 1 diabetes (T1D) risk genotype: DQ2 (DQA*0501-DQB*0201) and DQ8 (DQA*0301-DQB*0302). DBP: VD-binding protein.