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. 2013 Feb 15;4:19. doi: 10.3389/fphys.2013.00019

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Copyright © 2013 Karagueuzian, Nguyen, Qu and Weiss.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Masson trichrome staining in adult and aged rat and middle-aged rabbit ventricles. Notice increased fibrosis in the aged compared to adult LV (top figures) with almost complete fibrosis at the endocardium (Endo) with intermediate fibrosis of the posterior left ventricle (LV) and the septum (blue color). Lower panels show LV fibrosis in the middle aged compared to adult rabbit LV. Ant, anterior; RV, right ventricle; Post, posterior; Epi, epicardium [from Sato et al., 2009 and Morita et al., 2009 (Lokuta et al., 2005)].