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. 2013 Feb 15;4:19. doi: 10.3389/fphys.2013.00019

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Copyright © 2013 Karagueuzian, Nguyen, Qu and Weiss.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Promotion of EADs by myofibroblast-myocyte coupling (M-F) during oxidative stress. Coupling a patch-clamped myocyte superfused with normal Tyrode's solution to a virtual fibroblast promotes no EADs (A). However, coupling lowers the AP plateau and shortens APD as shown in the superimposed traces at a faster time scale in panel (B). Panel (C) (top traces) shows lack of EAD induction with 0.1 mmol/L H2O2 in the uncoupled state. However, coupling the myocyte to a virtual fibroblast (C_f 6.3 pF, Gj 3.0 nS) caused EADs to reappear, which were more prominent when Ef was −25 mV (bottom traces) than −50 mV (middle traces). C_f is fibroblast capacitance in pF, Gj is M-F gap junctional conductance in nS, and E_f is the resting potential of the fibroblast in mV (from Nguyen et al., 2012).