Figure 3. 7-day LacZ gene expression in the alveolar region.

(a) A grouping of LacZ-expressing alveolar cells are present together with an alveolar macrophage (arrow). Examples of (b) Type I pneumocyte transduction, and (c) Type II pneumocyte transduction of several adjacent cells with strong nuclear LacZ staining that has bled into the cytoplasm; (d) and (e) show examples of alveolar macrophage staining showing evidence of phagocytic LacZ staining (blue granules within the cytoplasm) and direct cellular transduction (blue nuclear staining; arrow), respectively. Scale bar 50 μm.