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. 2012 Jun;3(3):131–146. doi: 10.1177/2040620712437754

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© The Author(s), 2012

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Figure 1. — Morphologic findings in essential thrombocytosis (ET) and myelofibrosis (MF).

(A), (B) A 39-year-old woman with JAK2^V617F+ ET. Mildly hypocellular (50%) marrow (5× H&E) with balanced trilineage hematopoiesis featuring singly scattered and focally clustered normal sized and large megakaryocytes with widely spaced (‘staghorn’) nuclei (20× H&E). (C), (D) A 55-year-old woman with JAK2^V617F+ MF. Markedly hypercellular (95% cellularity) marrow (5× H&E) with granulocytic hyperplasia and prominent aggregates of smaller cytologically atypical megakaryocytes with hypolobated ‘cloudlike’ nuclei (20× H&E).