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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012 Sep 13;5(1):31–48. doi: 10.1002/wnan.1197

Figure 3.

Figure 3

Tumor accumulation was enhanced with removal of PEG from tumor-localized stealth liposomes (SL). TAT-functionalized liposomes with cleavable disulfide-linked PEG (C-TAT-SL) accumulated in C26 colon cancer tumors via the EPR effect prior to the intravenous administration of thiol-reactive cysteine (Cys). Local cleavage and release of the PEG increased the cellular uptake in the tumor by 56% in cysteine administered animals, compared to the PBS administered controls, as measured by flow cytometry of excised tumor cells. This tumor uptake was 130% greater than that achieved with controls including non-functionalized stealth liposomes (SL), non-cleavable PEG coated TAT-liposomes (N-TAT-SL), and cleavable PEG coated non-functionalized liposomes (C-SL). Reprinted with permission from Ref 70. Copyright 2011 American Chemical Society.