Table 5.
Recommendation percentages for Phase II experimentation under the three-parameter model and the average percentage of true MTDs selected by the design.
| Toxicity (%) | Design | ||||||
|---|---|---|---|---|---|---|---|
| D1 Ω1 | D1 Ω2 | D1 Ω3 | D2 Ω1 | D2 Ω2 | D2 Ω3 | ||
| Scenario 1: in agreement with prior | |||||||
| Far below TTL 0–14 | 1.6 | 2.3 | 2.0 | 3.2 | 3.5 | 3.5 | |
| Below TTL 15–24 | 26.0 | 24.1 | 21.8 | 27.2 | 25.4 | 25.8 | |
| TTL 25–34 | 49.7 | 47.3 | 50.1 | 47.3 | 43.9 | 43.7 | |
| Above TTL 35–44 | 21.7 | 25.3 | 24.9 | 21.5 | 26.5 | 26.1 | |
| Far above TTL ≥ 45 | 1.0 | 1.1 | 1.1 | 0.8 | 0.7 | 0.8 | |
| % of MTDs selected | 14 | 14 | 15 | 19 | 15 | 14 | |
| Scenario 2: toxic | |||||||
| Far below TTL 0–14 | 3.5 | 2.7 | 2.6 | 4.8 | 5.1 | 4.9 | |
| Below TTL 15–24 | 31.5 | 24.9 | 25.2 | 32.8 | 29.2 | 29.4 | |
| TTL 25–34 | 39.4 | 46.7 | 47.9 | 34.7 | 40.3 | 40.9 | |
| Above TTL 35 - 44 | 20.3 | 21.0 | 20.8 | 21.6 | 20.9 | 19.2 | |
| Far above TTL ≥ 45 | 5.3 | 4.7 | 3.5 | 6.2 | 4.5 | 5.6 | |
| % of MTDs selected | 17 | 20 | 19 | 21 | 20 | 19 | |
| Scenario 3: asymmetric toxic | |||||||
| Far below TTL 0–14 | 1.2 | 1.4 | 1.5 | 1.3 | 2.0 | 1.5 | |
| Below TTL 15–24 | 17.4 | 18.7 | 19.0 | 18.7 | 18.3 | 17.6 | |
| TTL 25–34 | 39.0 | 39.2 | 39.1 | 35.8 | 39.1 | 40.5 | |
| Above TTL 35–44 | 38.1 | 37.6 | 36.9 | 39.0 | 36.1 | 35.9 | |
| Far above TTL ≥ 45 | 4.3 | 3.0 | 3.6 | 5.2 | 4.4 | 4.5 | |
| % of MTDs selected | 11 | 11 | 10 | 15 | 13 | 13 | |
| Scenario 4: flat | |||||||
| Far below TTL 0–14 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
| Below TTL 15–24 | 17.1 | 11.7 | 11.1 | 16.3 | 12.4 | 11.0 | |
| TTL 25–34 | 71.5 | 74.5 | 73.7 | 69.0 | 73.1 | 72.9 | |
| Above TTL 35–44 | 11.4 | 13.8 | 15.1 | 14.7 | 14.5 | 16.1 | |
| Far above TTL ≥ 45 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
| % of MTDs selected | 6 | 5 | 5 | 6 | 7 | 7 | |
TTL, target toxicity level. MTD, maximum tolerated dose.