Table 3.

Patient and Tumor Characteristics Stratified by HER2 Status Tested by FISH and IHC (PATHWAY HER2/neu 4B5) in Surgical Specimens.

Clinicopathologic Variable	HER2 FISH-	HER2 FISH+	P	IIC 0/1+	IIC 2+/3+	P
Male sex	52/76 (68)	23/27 (85)	.051*	44/66 (67)	31/37 (84)	.032*
Mean age ± SD, years (n = 103)	69.5 ± 11.2	69.5 ± 10.6	.409†	70.1 ± 10.2	68.5 ± 12.3	.682†
Tumor location			.236*			.162*
Distal stomach	35/76 (46)	10/27 (37)		29/66 (44)	16/37 (43)
Proximal stomach	4/76 (5)	1/27 (4)		3/66 (5)	2/37 (6)
GEJ/distal esophagus	37/76 (49)	16/27 (59)		34/66 (51)	19/37 (51)
Mean tumor size ± SD, cm	5.8 ± 3.2	4.7 ± 1.8	.164†	5.8 ± 3.2	4.9 ± 2.1	.157†
Lauren histotype			.038*			.028*
Intestinal	61/76 (80)	26/27 (96)		52/66 (79)	35/37 (95)
Diffuse	15/76 (20)	1/27 (4)		14/66 (21)	2/37 (5)
Ming histotype			.658*			.834*
Expanding	32/76 (42)	10/27 (37)		26/66 (39)	16/37 (43)
Infiltrative	44/76 (58)	17/27 (63)		40/66 (61)	21/37 (57)
Tumor grade			.059*			.131*
Low (G1 or G2)	45/76 (59)	22/27 (81)		39/66 (59)	28/37 (76)
High (G3)	31/76 (41)	5/27 (19)		27/66 (41)	9/37 (24)
Pathologic T stage			.618*			.115*
T1	6/76 (8)	4/27 (15)		5/66 (8)	5/37 (14)
T2	14/76 (18)	5/27 (18.5)		10/66 (15)	9/37 (24)
T3	30/76 (40)	13/27 (48)		29/66 (44)	14/37 (38)
T4	26/76 (34)	5/27 (18.5)		22/66 (33)	9/37 (24)
Pathologic N stage‡			.806*			.821*
N0	21/73 (29)	9/27 (33)		18/63 (29)	12/37 (32)
N1, N2, or N3	52/73 (71)	18/27 (67)		45/63 (71)	25/37 (68)
Pathologic M stage, M1	8/73 (11)	2/27 (7)	.729*	7/63 (11)	3/37 (8)	1*
Stage group‡			1*			.837*
I	11/73 (15)	7/27 (26)		9/63 (14)	9/37 (24)
II	20/73 (27)	4/27 (15)		18/63 (29)	6/37 (16)
III	38/73 (52)	13/27 (48)		32/63 (51)	19/37 (52)
IV	4/73 (6)	3/27 (11)		4/63 (6)	3/37 (8)

IIC, IHC score; GEJ, gastroesophageal junction.

Data are given as number/total (percentage).

^*Fisher exact test.

^†Mann-Whitney U test.

^‡Missing data are because of lymph node absence in the surgical specimen (pNx).