Figure 4.

Alignment tree of multiple sclerosis (MS) RNA and DNA clones with reference multiple sclerosis associated retroviral element (MSRV), Human Endogenous Retroviral family ‘W’ (HERV-W) (ERVWE1 and ERVWE2) sequences and distant HERV-K envelope (Env) sequence. ClustalW (v1.83) multiple alignment parameters: open gap penalty=10.0; extend gap penalty=5.0; delay divergent=40%. Transitions: weighted. The calculated distance between branched clones is indicated by the horizontal length separating them (reference length unit represented at the bottom), or by the numbers on the lines (when not proportional). The total distance between two clones is the addition of these measures.