Table 2.
HERV-W Env protein detection in multiple sclerosis (MS) and clinically isolated syndrome (CIS) serum compared to normal population.
| Positive | Negative | Highest value | Mean value | Mean of positives | Tested (N) | Statistics* | |
|---|---|---|---|---|---|---|---|
| MS | 80% | 20% | 5.34 | 1.70 | 1.92 | 74 | p < 0.001 |
| CIS | 64% | 36% | 1.62 | 1.11 | 1.30 | 14 | p = 0.002 |
| Blood donors | 0% | 100% | 0.90 | 0.75 | NA | 26 |
*
Mann–Whitney rank sum test: statistical significance of the observed difference between patients versus blood donors.
The maximum statistical value of normal population (cut-off) has been determined from the series of reference serum of healthy blood donors (cut-off = mean + 2SD), the value is expressed as the ratio of the measured ELISA (Enzyme-Linked Immunosorbent Assay) value to the cut-off value from normal population of blood donors.