Figure 10.
Production of proinflammatory cytokines by HSP27 stimulated bone marrow derived dendritic cells (BMDCs) from C3H/HeN mice can be blocked by anti-HSP27 antibodies. Cultures were treated with HSP27 in a manner identical to that of Figure 9. Antibodies to HSP27 were added to separate cultures. There was a significant increase in IL-12p35, (*p<0.05) and IL-12p40, production and upon addition of HSP27 antibody (5mg/ml) there was significantly less production of these cytokines. There were two mice per group and each experiment was repeated twice with identical results. The data shown are from one representative experiment.
