Skip to main content
. Author manuscript; available in PMC: 2013 Feb 15.
Published in final edited form as: J Immunol. 2009 Jan 1;182(1):675–683. doi: 10.4049/jimmunol.182.1.675

Figure 5.

Figure 5

Application of anti-HSP antibodies to the skin inhibits contact hypersensitivity to DNFB through a local effect. C3H/HeN mice were treated with anti-HSP27 or anti-HSP70 antibody on the abdomen or back as indicated. All mice, with the exception of the negative control, were then sensitized with DNFB on the abdomen. Application of hapten to the antibody treated site produced significant inhibition of the contact hypersensitivity response (**p<0.001). In contrast, administration of anti-HSP27 or HSP70 antibodies to the back but with hapten sensitization to the abdomen resulted in an ear swelling response that was not significantly different (p>0.05) from the PBS treated control. Results are expressed as change in auricular thickness ± SEM. There were four mice per group and each experiment was repeated twice with identical results. The data shown are from one representative experiment.