Figure 6.
Application of DNFB to sites of HSP treatment renders mice tolerant to that hapten. C3H/HeN mice were treated with HSP antibody on the shaved abdomen. DNFB was applied to the antibody site as described elsewhere. Fourteen days later, mice were sensitized with DNFB on the shaved back and were subsequently ear challenged after 5 days. Ear swelling responses indicate that the inhibition of CHS response produced by the HSP antibody persisted and was significant (*p<0.05, **p<0.001) in these mice. Results were expressed as change in auricular thickness ± SEM. There were four mice per group and each experiment was repeated twice with identical results. The data shown are from one representative experiment.
