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Influence of selected cytokines and growth factors on the IL-33 synthesis in RA-SFs. RA-SFs (n=4) were stimulated for 24 h with TNF-α, IL-1β, IL-18, PDGF-BB or TGF-1β (concentrations as indicated in the figure). Synthesis of IL-33 in the cell lysates was analyzed by ELISA (A) or in cells by immunohistochemistry using a specific antibody against IL-33. (B) Representative results are shown. +P≤0.05 Mann-Whitney U-test vs. control. Bars indicate means ± SEM.
