Appendix.
ICD9 Codes for Medical Conditions and Medications Associated with Osteoporosis and Additional Detail on Covariate Definitions
|
Medical conditions associated with osteoporosis | |||
|---|---|---|---|
| Condition | ICD9 code | Condition | ICD9 code |
| Adrenal insufficiency | 255.4X, 255.5 | Marfan's syndrome | 759.82 |
| Anorexia nervosa | 307.1 | Multiple myeloma | 203.0X |
| Cushing syndrome | 255.0 | Osteogenesis imperfecta | 756.51 |
| Cystic fibrosis | 277.0X | Hemochromatosis | 275.0 |
| Hepatic or renal disease chronic | 571.XX, 585.X | Gaucher's disease | 272.7 |
| Hypercalciuria | 791.9 | Systemic mastocytosis | 202.6 |
| Hyperparathyroidism | 588.81, 252.0X, 259.3 | Rheumatologic diseases | 710.0, 710.1, 710.3, 714.X |
| Hyperthyroidism/thyrotoxicosis | 242.XX | Rickets/vitamin D deficiency | 268.X |
| Hypogonadism | 257.2 | Spinal cord injury | 806.XX, 952.X, 767.4 |
| Hypophosphatasia | 275.3 | Malabsorption syndrome | 579.X |
| Medications associated with osteoporosis | ||
|---|---|---|
| Heparin | Anticonvulsants | Other |
| Heparin | Phenytoin | Selective serotonin reuptake inhibitors |
| Enoxaparin | Primidone | Cyclosporine |
| Dalteparin | Phenobarbital | Depot medroxyprogesterone acetate |
| Enoxaparin | Carbamazepine | |
| Fondaparinux | ||
| Tinzaparin | ||
| Other covariates | |
|---|---|
| History of fracture | ICD9 codes for fractures in hip (820.XX-821.XX), vertebral (805.XX), humerus (812.XX), forearm and wrist (813.XX-814.XX) |
| Diabetes | Defined as having 1) two fasting plasma glucoses ≥126 mg/dL, two nonfasting glucoses ≥200 mg/dL, or one of each, 2) one or more hemoglobin A1c ≥7.0%,3) one or more dispensing for insulin or oral diabetic agents, or 4) an inpatient diagnosis code of diabetes (250.XX) |
| Depression | ICD9 codes (296.2X, 293.3X, 311, 300.4, 309.0, 309.28) |
| Corticosteroid use | Oral forms of medications in the American Hospital Formulary Service (AHFS) class 68.04 |