Table II.
Non-alcoholic fatty liver disease (NAFLD) activity score (NAS) of each experimental group assessed 8 weeks after the feeding with experimental diets.
| Characteristic | LETO/vehicle LV | OLETF/vehicle OV | OLETF/MCD OM | OLETF/MCD+Silymarin OMS |
|---|---|---|---|---|
| Steatosis | 0.00±0.00 | 0.75±0.50 | 3.00±0.00 | 3.00±0.0 |
| Inflammation | 0.00±0.00 | 0.00±0.00 | 2.13±0.64 | 1.80±0.83 |
| Ballooning | 0.00±0.00 | 0.00±0.00 | 1.88±0.35 | 1.80±0.44 |
| NAS | 0.00±0.00 | 0.75±0.50 | 7.00±0.76a,b | 6.00±0.70a,b |
Pathological analysis of NAFLD and NAS was performed according to the suggestion by Kleiner et al (21). Data are expressed as mean ± SD.
a
P<0.05 as compared with LETO/vehicle;
b
P<0.05 for the OLETF/MCD vs. the OLETF/MCD+silymarin group.