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. 2013 Feb 15;450(Pt 2):351–363. doi: 10.1042/BJ20121371

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© 2013 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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(A–D) Cardiomyocytes were exposed to A61603 for the times indicated and mRNA expression was measured by qPCR. Results expressed relative to controls are means±S.E.M. for four independent experiments. Expression profiles are grouped according to temporal regulation. (E–G) Adult rat hearts were perfused retrogradely under control conditions (white bars), with A61603 alone (black bars) or with A61603 in the presence of PD184352 (grey bars). (E) mRNAs significantly up-regulated by A61603 with significant inhibition by PD184352. (F) mRNAs significantly up-regulated by A61603 without significant inhibition by PD184352. (G) mRNAs not significantly up-regulated by A61603. Results are means±S.E.M. for at least four hearts per condition. *P<0.001, **P<0.01 and @P<0.05 relative to control; #P<0.001, †P< 0.01 and ‡P<0.05 relative to A61603 alone.