Table 2.
Effect of bichalcophenes on Salmonella typhimurium TA1535 viability as assessed by colony formation on plate
| Compound |
Viability at bichalcophene concentrationsa (colonies/plate (% of control))
|
|
|---|---|---|
| 5/10 μM | 10/20 μM | |
| None | 45.7 ± 2.2 (100) | |
| 1A | 54.3 ± 3.3 (119) | 45.0 ± 2.5 (98) |
| 1B | 61.7 ± 2.7 (135) | 55.3 ± 3.6 (121) |
| 2A | 88.3 ± 5.4 (193)b | 47.0 ± 4.5 (103) |
| 2B | 44.7 ± 3.6 (98) | 46.7 ± 3.2 (102) |
| 3A | 46.7 ± 4.8 (102) | 42.3 ± 1.9 (93) |
| 3B | 42.7 ± 4.8 (93) | 43.3 ± 2.5 (95) |
| 4A | 41.3 ± 6.4 (90) | 63.7 ± 3.8 (139)b |
| 4B | 39.7 ± 4.5 (87) | 40.0 ± 2.1 (88) |
| 5A | 40.3 ± 2.9 (88) | 45.7 ± 3.0 (100) |
| 5B | 41.7 ± 1.8 (91) | 41.3 ± 2.8 (90) |
Notes:
a
Concentrations investigated for all compounds were 10 and 20 μM except for compounds 1B and 5B – the concentrations used were 5 and 10 μM;
b
significantly different (P < 0.05) from the number of colonies/plate (mean ± SEM) recorded in the absence of bichalcophenes. Assays were performed in triplicates with a 10−7 dilution of an overnight Salmonella typhimurium TA1535.
Abbreviation: SEM, standard error of the mean.