Figure 3.

Association between SDHB mutation, tumor suppressor gene hypermethylation, and metastasis. Methylation densities are illustrated for individual tumors in Series A+B from patients with predisposing mutations and/or syndromic disease related to SDHB, RET/MEN2, NF1, or VHL/VHL. Tumors with MetI levels above cutoff are indicated by dark blue boxes, above cutoff for one or more CpG sites by light blue boxes, and below cutoff levels by green boxes. Cutoff levels for individual genes are >30% for DCR2 and RASSF1A and >10% for CDH1, NORE1A, P16, and RARB. Cases with metastasis are indicated to the right. *Metastasis from the tumor in the row above.