Table 2.
Autopsy non-HIV controls and Alzheimer's disease cases
| Brain | Sestrin-2 | p-Tau gradec | Age | Sex | PMI (h) | |
|---|---|---|---|---|---|---|
| Control | Patterna | |||||
| C1 | RF | N | 1 | 72 | F | 16 |
| C2 | RP | N | 0 | 43 | F | 30 |
| C3 | RP | N | 0 | 90 | F | 12 |
| C4 | LF | N | 1 | 76 | M | n/a |
| C5 | LF | N | 0 | 33 | F | 10 |
| C6 | RF | N | 0 | 35 | F | 15 |
| C7 | RF | N | 0 | 72 | M | 26 |
| C8 | LF | N | 0 | 24 | M | 21 |
| C9 | RF | N | 1 | 14 | M | 22 |
| C10 | LF | N | 1 | 48 | F | 12 |
| C11 | LF | N | 1 | 32 | M | 22 |
| C12 | LF | N | 0 | 33 | M | 26 |
| C13 | LF | N | 0 | 47 | F | 15 |
| C14 | LF | NS | 1 | 55 | F | 3 |
| C15 | LF | NS | 0 | 53 | M | 8 |
| C16 | LF | NS | 1 | 68 | n/a | 3 |
| C17 | LF | NS | 0 | 48 | M | 14 |
| C18 | LF | S | 0 | 26 | M | 7 |
| Alzheimer's disease | Neurofibrillaryb | |||||
| A1 | LF / RH | + / + | 3 / 3 | 81 | F | 20 |
| A2 | LF / LH | + / + | 3 / 3 | 75 | F | 7 |
| A3 | LF / LH | + / + | 2 / 3 | 83 | M | 5 |
| A4 | LF / RH | + / + | 3 / 3 | 69 | M | 24 |
| A5 | LF / LH | + / + | 3 / 3 | 86 | F | 7 |
| A6 | RF / RH | + / + | 3 / 3 | 90 | M | 13 |
| A7 | RF / LH | + / + | 3 / 3 | 90 | M | 72 |
| A8 | LF / RH | + / + | 3 / 3 | 72 | F | 16 |
| A9 | RF / LH | + / + | 3 / 3 | 86 | F | 24 |
| A10 | RF / LH | + / + | 2 / 3 | 85 | F | 22 |
| A11 | LF / RH | + / + | 3 / 3 | 87 | M | 24 |
| A12 | RF / LH | + / + | 3 / 3 | 69 | F | 15 |
| A13 | LF / RH | + / + | 3 / 3 | 76 | F | 21 |
| A14 | LP / RH | + / + | 3 / 3 | 89 | M | 15 |
| A15 | LF / LH | + / + | 3 / 3 | 74 | F | 13 |
| A16 | RF / LH | + / + | 3 / 3 | 89 | F | 4 |
| A17 | RF / LH | + / − | 3 / 3 | 85 | F | 96 |
| A18 | LF / RH | − / + | 2 / 3 | 97 | F | 4 |
| A19 | LF / LH | − / − | 3 / 3 | 86 | F | 72 |
Abbreviations: HIV, human immunodeficiency virus; p-Tau, phospho-Tau; PMI, postmortem interval; RF, right mid-frontal; LF, left mid-frontal; RP, right parietal; LP, left parietal; RH, right hippocampus; LH, left hippocampus; M, male; F, female; n/a, data not available; +, presence; −, absence.
Sestrin-2 immunoreactivity in the isocortex of non-HIV controls is classified into three patterns: neuropil predominance (N), neuropil and neuronal-soma co-dominance (NS), and neuronal-soma predominance (S).
Sestrin-2-immunoreactive neurofibrillary lesions (i.e. neurofibrillary tangles and plaque-associated dystrophic neurites) in the isocortex and hippocampus, respectively, of each Alzheimer's disease brain.
The density of p-Tau-immunoreactive neuropil threads is graded as 0, 1, 2, and 3 (Alafuzoff et al. 2008). In each Alzheimer's disease brain, p-Tau grades are shown for the isocortex and hippocampus, respectively