Table 3.
PK parameters | Pazopanib alone
|
Pazopanib + GF120918
|
||
---|---|---|---|---|
Plasma | Brain | Plasma | Brain | |
λz(h−1) | 0.50 | 0.37 | 0.38 | 0.25 |
Half-life (h) | 1.39 | 1.89 | 1.83 | 2.75 |
Clearance (ml/min/kg) | 2.38 | 2.49 | ||
Volume of distribution (ml/kg) | 285.86 | 398.22 | ||
AUC (0 → tlast) (mg min/ml) | 1.356 ± 0.043 | 0.020 ± 0.001 | 1.029 ± 0.071 | 0.042 ± 0.003 |
AUC (0 → tlast) brain/AUC (0 → tlast) plasma | 0.015 | 0.041 |