Table 3.

Plasma and brain pharmacokinetic parameters obtained by noncompartmental analysis of the concentration-time profile data after an i.v. bolus dose of pazopanib in absence and presence of elacridar (GF120918) in FVB wild type mice.

PK parameters	Pazopanib alone		Pazopanib + GF120918
	Plasma	Brain	Plasma	Brain
λz(h−1)	0.50	0.37	0.38	0.25
Half-life (h)	1.39	1.89	1.83	2.75
Clearance (ml/min/kg)	2.38		2.49
Volume of distribution (ml/kg)	285.86		398.22
AUC (0 → tlast) (mg min/ml)	1.356 ± 0.043	0.020 ± 0.001	1.029 ± 0.071	0.042 ± 0.003
AUC (0 → tlast) brain/AUC (0 → tlast) plasma	0.015		0.041