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. Author manuscript; available in PMC: 2013 Feb 15.
Published in final edited form as: Curr Alzheimer Res. 2007 Apr;4(2):205–212. doi: 10.2174/156720507780362083

Figure 3. Overlap of aging-related and corticosterone (Cort)-sensitive genes.

Figure 3

Using microarray technology, the genes that were aging-sensitive (upper) and also Cort- sensitive (lower) were identified. Numbers shown represent the number of genes in each category of directional change (down or up). Most genes downregulated with aging are expressed primarily in neurons, whereas upregulated genes are primarily glial. More genes were altered in opposite directions by Cort and aging than in the same direction, contravening a key prediction of the original GC hypothesis. Selected processes (and some genes from which they were identified) are shown for each directional combination of Cort and aging changes.