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. 2012 Nov 8;6:138. doi: 10.1186/1752-0509-6-138

Table 1.

Parameters of ER binding with ligands and DNA ERE

Reaction Kd Value in the model, nM Existing experimental estimates, nM Reference
ER+ER=ER2
 K1
 25
 >50
 [73]
ER2+H=ER2H
 K2
 0.2
 0.16
 [23]
ER2H+H=ER2H2
 K3
 0.1
 -
  
ER+H=ERH
 K4
 0.25
 0.9
 [31]
ERH+ER=ER2H
 K5*
 20
 50
 [73]
ERH+ERH=ER2H2
 K6*
 8
 4
 [33]
 
  
  
 20
 [73]
ER2+I=ER2I
 K7
 10
 -
  
ER2I+I=ER2I2
 K8
 150
 220
 [31]
ER+I=ERI
 K9
 30
 -
  
ERI+ER=ER2I
 K10*
 8.3
 < K5
 [23]
ERI+ERI=ER2I2
 K11*
 41.5
 -
  
ERH+ERI=ER2HI
 K12*
 26.67
 -
  
ER2I+H=ER2HI
 K13
 0.8
 -
  
ER2H+I=ER2HI
 K14*
 40
 -
  
ER2+D=ER2D
 K15
 8
 40
 [35]
 
  
  
 2.5
 [36]
ER2H+D=ER2HD
 K16
 2.4
 -
  
ER2H2+D=ER2H2D
 K17
 1.2
 1.8 ±0.6
 [36]
 
  
  
 2.0±0.3
 [27];
 
  
  
 10
 [35]
ER2I+D=ER2ID
 K18
 50
 -
  
ER2I2+D=ER2I2D
 K19
 87
 14
 [37]
ER2HI+D=ER2HID K20 10-20 -  

Parameters marked by (*) are dependent on the values of others and have been calculated as described in Methods.