Table 2.

Selected details of the 22 studies of FEV₁ and lung cancer

Study REF	Reference(s)	Location	Baseline population	Follow-up period (years)	Lung cancer cases	Newcastle-Ottawa scorea
BEATY	[23]	USA, Baltimore	874 men aged 17+ entering study on aging between 1958 and 1979	24	15	7
CALABR	[1]	Italy, multicentre	3804 male and female current or former smokers aged 50–75 entering study between 2000 and 2008	5	57	6
CARET	[25,26]	USA, multicentre	3033 male asbestos exposed heavy smokers aged 45–74 entering study between 1985 and 1994	20	205	8
CARTA	[19]	Italy, Sardinia	696 male silicotics aged up to 74 entering study between 1964 and 1970	23	22	6
FINKEL	[27]	Canada, Ontario	733 male radon exposed uranium miners studied in 1974	18	42	5
ISLAM	[4,38]	USA, Michigan	3956 men and women aged 25+ entering community health study between 1962 and 1965	25	77	9
LANGE	[5]	Denmark, Copenhagen	13946 men and women aged 20+ entering heart health study between 1976 and 1978	12	225	8
MALDON	[31]	USA, Minnesota	1520b male and female current or former smokers aged 50+ studied in 1999	4	64	5
MANNIN	[32]	USA, national	5402 men and women aged 25–74 participating in NHANES between 1971 and 1975	22	113	9
MRFIT	[2,30]	USA, multicentre	6613 men aged 35–57 at high risk of heart disease participating in the Multiple Risk Factor Intervention Trial between 1973 and 1982	26	363	8
NOMURA	[7]	USA, Hawaii	6317 Japanese-American men aged 46–68 entering study between 1965 and 1968	22	172	8
PETO	[35]	UK, five areas	2718 men in occupational groups aged 25–64 entering study between 1954 and 1961	25	103	7
PURDUE	[37]	Sweden, national	176997 male construction workers entering study between 1971 and 1993	31	834	7
RENFRE	[3,28]	Scotland, two cities	15244 men and women aged 45–64 entering study between 1972 and 1976	23	651	8
SKILLR	[9]	USA, Minnesota	226c men and women aged 45–59 living in rural areas entering study between 1973 and 1974	11	11	7
SPEIZE	[20]	USA six cities	8427 men and women aged 25–74 entering study between 1974 and 1977	12	61	8
STAVEM	[21]	Norway, Oslo	1623 male workers in five companies aged 40–59 entering study between 1972 and 1975	26	42	7
TAMMEM	[39]	Canada, British Columbia	2596 male and female current and former smokers of 20+ pack-years aged 40+ studied in 1990	17	154	8
TOCKMA	[10]	USA, Baltimore	3728 male current smokers and recent quitters, smoking 1+ packs/day, aged 45+ studied in 1987	2d	19	7
VANDEN	[40]	USA, California	153925 male and female members of the Kaiser Permanente Medical Care Program entering study between 1964 and 1972	24	1514	9
WILES	[43]	South Africa, national	2062 male gold miners aged 45–54 entering study between 1968 and 1970	18	74	5
WILSON	[44]	USA, Pennsylvania	1553 male and female current or former smokers of 10+ cigs/day for 25+ years with FEV1/FVC <0.7, aged 50–79, entering study from 2002	5	67	6

^a See Methods for a description of this score. The maximum possible value is 9.

^b Nested case–control analysis involving 64 cases and 377 controls drawn from original population of 1520.

^c Nested case–control analysis involving 113 men and women with FEV₁ <70% predicted, and 113 with FEV₁ of 85% or more drawn from a study with original sample size not stated.

^d Although the mean follow-up was less than 3 years, follow-up for some subjects was 3 years or more, so the study was not considered to have failed the inclusion criteria.