Table 4. Percentages and Chi-Square Statistic of Serotonin System Genotypes according to CU Group.
Gene | SNP | Low CU (N = 92) | High CU (N = 41) | χ2 | ||||
Minor Homozygote | Heterozygote | Major Homozygote | Minor Homozygote | Heterozygote | Major Homozygote | (N = 133) | ||
HTR1A | rs6295 | 26 | 54 | 20 | 34 | 39 | 27 | 2.49 |
HTR1B | rs13212041 | 46 | 54 | 43 | 57 | 0.11 | ||
rs6296 | 11 | 31 | 58 | 5 | 49 | 46 | 4.08 | |
rs130058 | 11 | 37 | 52 | 5 | 56 | 39 | 4.57 | |
rs11568817 | 22 | 37 | 41 | 7 | 68 | 24 | 11.63* # | |
HTR2A | rs6314 | 29 | 71 | 7 | 93 | 7.88* # | ||
rs6311 | 20 | 45 | 35 | 20 | 34 | 46 | 1.54 | |
HTR3B | rs1176744 | 15 | 39 | 46 | 18 | 37 | 45 | 0.18 |
TPH1 | rs1800532 | 12 | 38 | 50 | 20 | 44 | 37 | 2.49 |
rs211105 | 6 | 47 | 47 | 10 | 37 | 53 | 1.18 | |
TPH2 | rs4570625 | 40 | 60 | 40 | 60 | 0.00 | ||
rs11178997 | 10 | 90 | 15 | 85 | 0.72 | |||
rs7305115 | 21 | 42 | 37 | 15 | 56 | 29 | 2.17 | |
rs4565946 | 19 | 52 | 29 | 13 | 52 | 35 | 0.64 | |
SLC6A4 | rs2066713 | 25 | 35 | 40 | 22 | 46 | 32 | 1.64 |
Note:
represents p<0.01 (2-tailed),
represents p<0.05 after FDR adjustment for 15 comparisons. SNPs located on the same chromosome are listed in order of their position along the gene.