Table 3. Association of MicroRNA SNPs with OSCC Risk.
Genotype | Cases (n = 325) | Controls (n = 335) | P * | Adjusted OR (95% CI)† | ||||
No. | % | No. | % | Overall OSCC | SCCOP | SCC of Oral Cavity | ||
miR146 rs2910164 | 0.299 | |||||||
GG (Ref.) | 184 | 56.6 | 203 | 60.6 | 1.0 | 1.0 | 1.0 | |
CG+CC | 141 | 43.4 | 132 | 39.4 | 1.3 (0.9–1.8) | 1.9 (1.3–3.0) | 1.0 (0.6–1.4) | |
miR149 rs2292832 | 0.947 | |||||||
CC (Ref.) | 158 | 48.6 | 162 | 48.4 | 1.0 | 1.0 | 1.0 | |
CT+TT | 167 | 51.4 | 173 | 51.6 | 0.9 (0.7–1.3) | 1.0 (0.7–1.5) | 0.9 (0.6–1.3) | |
miR196 rs11614913 | 0.871 | |||||||
CC (Ref.) | 95 | 29.2 | 96 | 28.7 | 1.0 | 1.0 | 1.0 | |
CT+TT | 230 | 70.8 | 239 | 71.3 | 1.0 (0.7–1.4) | 1.0 (0.7–1.6) | 1.0 (0.6–1.5) | |
miR499 rs3746444 | 0.060 | |||||||
TT (Ref.) | 184 | 56.6 | 214 | 63.9 | 1.0 | 1.0 | 1.0 | |
CT+CC | 141 | 43.4 | 121 | 36.1 | 1.3 (0.9–1.9) | 1.6 (1.0–2.4) | 1.1 (0.8–1.7) |
Genotype distributions for miR146 rs2910164, miR149 rs2292832, miR196 rs11614913, and miR499 rs3746444 between patients and controls.
ORs were adjusted for age, sex, smoking, alcohol drinking, and HPV16 serology.