Table 1.
Description of the five cohorts
| Cohort Description* | COHRA | DRDR1 | DRDR2 | ARIC | HPFS |
|---|---|---|---|---|---|
|
PI |
Marazita |
Vieira & Marazita |
Vieira |
Boerwinkle |
Hu |
|
Sample Size† |
970 |
223 |
290 |
4230 |
1730 (male) |
|
Age§ |
34.3 ± 9.4 |
41.9 ± 16.9 |
41.8 ± 17.9 |
63.1 ± 5.6 |
65.2 ± 8.4 |
|
Age Range |
17-67 |
17-84 |
17-89 |
53-75 |
49-83 |
|
Caries Prevalence (%) |
95.3 |
94.5 |
97.7 |
99.5 |
98.7 |
|
Caries Phenotype¶ |
DMFS |
DMFS |
DMFS |
Proportion DFS |
Caries Severity |
|
Genotyping Platform |
Illumina 610-Quad |
Illumina 610-Quad |
Illumina 610-Quad |
Affymetrix 6.0 |
Affymetrix 6.0 |
|
Genotyping Cente** |
CIDR |
CIDR |
PITT-GPCL |
BICGA |
BICGA |
| Imputed data | Y | Y | N | Y | N |
* COHRA: Center for Oral Health Research in Appalachia cohort.
DRDR1: Dental Registry and DNA Repository cohort phase 1.
DRDR2: Dental Registry and DNA Repository cohort phase 2.
ARIC: Atherosclerosis Risk in Community cohort.
HPFS: Health Professionals Follow-Up Study cohort.
† All summary statistics and subsequent analyses only include genotyped non-Hispanic Whites.
§ Mean ± SD.
¶ DMFS: Decayed, Missing due to Decay, or Filled tooth surfaces.
Proportion DFS: Decayed or Filled tooth surfaces / total surfaces at risk.
Caries severity: total # of caries coded as 0, 1; 2–4; 5–9 and 10 or more.
** CIDR: the Johns-Hopkins Center for Inherited Disease Research;
PITT-GPCL: Genomics and Proteomics Core Laboratories at University of Pittsburgh.
BICGA: Broad Institute Center for Genotyping and Analysis at Harvard and MIT.