Table 2.
Effect size and P-values for top SNPs in three meta-analyses*
| Gene/SNPs | Chr | Base Pair position | Data Status† |
Effect Size§ |
P-value (Meta 1) | P-value (Meta 2) | P-value (Meta 3) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| COHRA | DRDR1 | DRDR2 | ARIC | HPFS | |||||||
|
RHOU |
|
|
|
|
|
|
|
|
|
|
|
| rs3936161 |
1 |
227336163 |
Illumina |
−1.95 |
7.17 |
-- |
−0.70 |
-- |
0.721 |
1.55E-05 |
6.76E-05 |
| rs12072775 |
1 |
227339176 |
Affymetrix |
−1.94 |
7.17 |
-- |
−0.71 |
0.007 |
0.725 |
4.23E-05 |
0.001 |
| rs9287022 |
1 |
227344972 |
Imputed |
−2.09 |
7.19 |
-- |
−0.61 |
-- |
0.673 |
3.79E-06 |
1.86E-05 |
| rs9793739 |
1 |
227352481 |
Imputed |
−2.08 |
7.88 |
-- |
−0.75 |
-- |
0.721 |
5.27E-07 |
4.28E-06 |
| rs2988738 |
1 |
227427128 |
Affymetrix |
0.67 |
9.55 |
-- |
−1.75 |
−0.15 |
0.567 |
2.02E-05 |
0.002 |
|
ADAMTS3 |
|
|
|
|
|
|
|
|
|
|
|
| rs788919 |
4 |
73572758 |
Illumina |
−1.40 |
−4.14 |
−3.56 |
−0.47 |
-- |
0.026 |
1.36E-04 |
1.02E-05 |
| rs4694123 |
4 |
73606652 |
Illumina |
−1.31 |
−2.94 |
−3.89 |
−0.46 |
-- |
0.038 |
1.18E-04 |
1.26E-05 |
| rs10805050 |
4 |
73612147 |
Illumina |
1.01 |
2.93 |
2.50 |
0.42 |
-- |
0.093 |
4.88E-06 |
1.68E-06 |
| rs788911 |
4 |
73632087 |
Illumina |
0.99 |
2.54 |
3.29 |
0.38 |
-- |
0.084 |
4.77E-06 |
1.46E-06 |
| rs1383934 |
4 |
73636388 |
Illumina |
1.19 |
3.20 |
3.70 |
0.64 |
-- |
0.046 |
1.77E-06 |
2.96E-07 |
|
RPS6K2 |
|
|
|
|
|
|
|
|
|
|
|
| rs505982 |
6 |
167095386 |
Imputed |
3.66 |
8.52 |
-- |
−0.35 |
-- |
8.93E-06 |
0.859 |
0.025 |
| rs635808 |
6 |
167097412 |
Illumina |
−4.21 |
−7.53 |
−8.30 |
0.44 |
-- |
1.06E-07 |
0.898 |
0.010 |
|
PTK2B |
|
|
|
|
|
|
|
|
|
|
|
| rs17057381 |
8 |
27416801 |
Affymetrix |
16.39 |
28.98 |
-- |
0.47 |
−0.03 |
4.02E-07 |
0.267 |
0.764 |
|
CNIH |
|
|
|
|
|
|
|
|
|
|
|
| rs1953743 |
14 |
53722229 |
Both |
−3.08 |
−6.55 |
−6.87 |
0.01 |
0.04 |
1.98E-06 |
0.371 |
0.027 |
| rs4251631 |
14 |
53945934 |
Illumina |
−3.78 |
−6.32 |
−10.02 |
−0.35 |
-- |
2.13E-07 |
0.013 |
1.80E-06 |
| rs11850320 |
14 |
53990173 |
Illumina |
−4.57 |
−7.93 |
−6.78 |
−0.33 |
-- |
9.92E-07 |
0.177 |
0.0003 |
| rs7150062 |
14 |
53997400 |
Both |
4.52 |
7.93 |
6.78 |
0.40 |
0.01 |
1.15E-06 |
0.295 |
0.001 |
| rs7143579 | 14 | 54010435 | Illumina | −4.42 | −7.15 | −7.89 | −0.42 | -- | 1.16E-06 | 0.137 | 0.0002 |
* Summarizes genes/regions containing at least one SNP with significant P-values ≤ 10E-7 (bolded); Listed are the first five most significant SNPs if more than five SNPs observed at the corresponding region;
† Illumina/Affymetrix/Both: SNP was genotyped in Illumina 610Quad/Affymetrix 6.0/both chips respectively;
Imputed: SNP data was generated by imputation only. “--" indicating the corresponding SNP was not genotyped in DRDR2 or
HPFS;
§ Effect size can be directly compared ONLY among Meta 1 cohorts (COHRA, DRDR1 and DRDR2).