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. 2013 Feb 15;8(2):e56481. doi: 10.1371/journal.pone.0056481

Figure 2. Localization of Cyr61 expression in the UUO kidneys.

Figure 2

Representative immunohistochemical staining for Cyr61 protein in the sham operation kidneys (A, D, G, J), and the UUO kidneys at day 1 (B, E, H, K) and day 10 (C, F, I, L) after surgery. Low-power field images (A–F) show the major distribution of Cyr61 in renal tubular epithelial cells. Images of corticomedullary junctions (A–C) disclose that Cyr61 staining was positive in all renal tubule segments within the renal cortex and medulla. High-power field images (G–I) reveal that Cyr61 expression in the tubular epithelial cells was prominent in the cytoplasm. The star marks (*) indicate the lack of significant positive stain in the fibrotic area. Negative control (NC) staining showed no signal (J–L). (M) Masson trichrome stain of the corresponding day 10 UUO kidney shows the blue staining of collagen. Scale bar = 100 µm.