Table 1. Urine and serum analyses and body weight.

	Controls w4	Cisplatin 4w	Controls 9w	Cisplatin 9w
Body weight (g)	375 ± 37	305 ± 17 a	406 ± 26	358 ± 37 b
Serum Creatinine (mg/dl)	0.30 ± 0.07	0.42 ± 0.04 a	0.27 ± 0.03	0.54 ± 0.13 b
Serum Mg2+ (mg/dl)	2.60 ± 0.40	2.71 ± 0.24	2.55 ± 0.34	2.90 ± 0.32
Serum Na+ (meq/l)	143.13 ± 3.21	147.37 ± 5.57	146.00 ± 6.47	146.50 ± 4.35
Serum K+ (meq/l)	5.66 ± 1.80	5.51 ± 0.61	5.51 ± 0.33	5.27 ± 0.90
FE Mg2+ (%)	9.23 ± 4.52	32.56 ± 21.50 a,b	9.06 ± 3.08	20.15 ± 8.60
FE Na+ (%)	0.19 ± 0.11	0.18 ± 0.15	0.11 ± 0.06	0.24 ± 0.20

Data are presented in 4 groups: control animals receiving vehicle only, cisplatin-treated animals (2.5 mg/kg/w during 3 weeks) at 4 and 9 weeks after treatment with vehicle or cisplatin. Data are presented as means ± SD. Statistics were performed using generalized linear models. ^ap<0.05 versus controls at 4 weeks, ^bp<0.05 versus controls at 9 weeks.