Table 2. Summary of binding properties of EBA-175 RII specific mAbs.
| mAb | RIIdomain [21] | Epitope | Cyclic F2βf binding** | |
| ELISA | SPR | |||
| R215 | F2c | Conformational | ± | + |
| R216* | F2 | Linear | − | ND |
| R217 | F2c | Conformational | + | + |
| R218 | F1 | Conformational | − | − |
| R256 | F2c | Conformational | − | ND |
SPR: surface plasmon resonance. ND: not determined.
*
Does not inhibit parasite growth in vitro [21].
**
None of the mAbs demonstrated binding to linear F2βf.
c
These mAbs were shown to compete against each other for binding by competition ELISA.