Figure 1. Schematic diagram of the targeting vector used in the generation of PAPP-A2 conditional deletion mice.

Shown are the locations of the targeted exon, homology arms, loxP and FRT sites, ampicillin resistance gene (AmpR), phosphoglycerate kinase promoter (PGK), neomycin resistance gene (Neo), bovine growth hormone poly A termination signal (pA), and genotyping primers. The sizes of the primers have been exaggerated for clarity.