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. 2013 Feb 15;8(2):e56257. doi: 10.1371/journal.pone.0056257

Figure 9. Development and ultrastructure of neuromuscular junction endplates is not affected by GAD67 deficiency at E18.5.

Figure 9

Neuromuscular junction endplates stained with anti-neurofilament plus anti-synaptophysin (green) and for muscle acetylcholine receptors with α-bungarotoxin (red). A and A’ show E18.5 wild type diaphragm neuromuscular junction endplates compared to GAD67-deficient (−/−) mice in B and B’. C and C’ show E18.5 wild type latissimus dorsi neuromuscular junction endplates compared to GAD67-deficient (−/−) mice in D and D’. E and E’ show E18.5 wild type gluteal neuromuscular junction endplates compared to GAD67-deficient (−/−) mice in F and F’. Electron micrographs of single neuromuscular junction endplates in the gluteal muscle show no ultrastructural differences between wild type (G) and GAD67-deficient (H) mice. Scale Bar: A, A’, B, B’, C, C’, D, D’, E, E’, F, F’, 20 µm; G, H, 500 nm.