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. Author manuscript; available in PMC: 2014 Feb 11.
Published in final edited form as: Cancer Cell. 2013 Jan 31;23(2):171–185. doi: 10.1016/j.ccr.2012.12.021

Figure 8. Proposed Model for EC-mediated Paracrine Activation of Notch Signaling in Colorectal Cancer Cells.

Figure 8

(A) The conical model for Notch pathway activation, where membrane bound ligands such as Jagged-1 activates Notch signaling in contacting cells.

(B) Schematic summarizing our proposed model for paracrine activation of the Notch pathway in CRC cells. ADAM17 cleaves membrane bound Jagged-1 on ECs, releasing an N-terminal soluble fragment that binds, and activates, Notch on CRC cells.