Skip to main content
. Author manuscript; available in PMC: 2014 Feb 11.
Published in final edited form as: Dev Cell. 2013 Jan 24;24(3):310–323. doi: 10.1016/j.devcel.2012.12.015

Figure 4. Defects in midgestation double knockout embryos.

Figure 4

(A) Representative images of mid-gestation E10.5 to E15.5 embryos of indicated genotypes. Notice the presence of normal, smaller size and exencephalic DKO embryos. Arrowheads point to exencephaly/neural tube defects. All embryos are from crosses of DKO male × Dhet female. (B) H&E staining for histological analysis of exencephaly. (C) Images, genotypes and weights of E18.5 and E19.5 litters from the indicated crosses. Arrowheads point to exencephaly/neural tube defects. (D) Summary of genotypes, phenotypes and Mendelian frequency of all mid and late gestation embryos.