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. Author manuscript; available in PMC: 2014 Feb 14.
Published in final edited form as: J Med Chem. 2013 Jan 22;56(3):902–914. doi: 10.1021/jm301372c

Scheme 4. Reagents and Conditions.

Scheme 4

a) Triphenylphosphine, 6-chloro-2-iodopurine, diisopropyl azodicarboxylate, anhydrous THF, 70%; b) 2M NH3 in i-PrOH, 70 °C, 64%; c) Iodotrimethylsilane, anhydrous CH2Cl2, 49%; d) Dowex-50 resin, MeOH:H2O (1:1, v/v), 55°C, 40% (14), 49% (15).