. Author manuscript; available in PMC: 2014 Feb 14.

Published in final edited form as: J Med Chem. 2013 Jan 22;56(3):902–914. doi: 10.1021/jm301372c

Table 2.

Structure and effects on ex vivo heart function of novel phosphate and phosphonate analogues after subcutaneous infusion for 28 days, as determined by isolated working heart preparation in the LAD ligation model of ischemic heart failure in mice. Structures are shown in Table 1.

Compound	+dP/dt (mmHg/sec)^a	n =
Vehicle control	6156 ± 356	21
Charged nucleotides
1	6508 ± 96^*	18
5	6553 ± 435^*	11
6	6581 ± 721^*	8
Masked nucleotides
7	6711± 726^*	9
9	6681± 528^*	9
14	5946± 337	9

at 10 µM, expressed as mean ± SEM.

P<0.05 vs. vehicle for all compounds except 14.

ND – not determined.